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Clinical studies, although limited in size, report improvements in irritability, hyperactivity, sleep quality, communication, and oxidative stress biomarkers following supplementation with vitamin C, CoQ10, folinic acid, and mitochondrial support formulations (Mousavinejad et al., 2018

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The one controlled insomnia trial showed modest effects at best

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We then performed hierarchical clustering of the similarity matrix, cutting the tree at different levels (2070 clusters)